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From boosting strength to building muscle to promoting brain health, the benefits of creatine supplementation are crystal clearand well documented. In fact, the Academy of Nutrition and Dietetics (formerly the Academy of Nutrition & Dietetics in the United States) has now issued a report on creatine supplementation and brain health recommending this nutritional supplement as a safe prescription for cognitive functioning that supports overall brain health. How Creatine Works It all begins with energy production from dietary fuel, stored in the form of creatine phosphate (CP), which is broken down by the mitochondria to create energy for muscle contraction. In fact, the body produces roughly 60 percent of all ATP in the body, making the body the primary source for muscle energy. It must be remembered that this is only muscle-derived energy, and that this energy is dependent on the metabolism of fats and carbohydrates. When the creatine phosphate is used up to make ATP (the body's main source of energy), creatine phosphate is excreted by the kidneys. Why Creatine Sustains Muscle Creatine has been utilized by athletes for decades in endurance and strength sports. The chemical compound acts as a natural antioxidant, improving overall brain and cognitive function. This is especially true for athletes that perform more high-intensity exercise that is likely to cause oxidative stress. To understand creatine's role it is important to review the role of creatine phosphate in muscle energy production. In brief the energy produced by glycogen in the muscles is broken down to produce adenosine triphosphate (ATP) which is used up primarily for ATP production (and a lesser amount for energy conversion). Once ATP generation stops, the ATP cycle is then over; the body uses glucose for fuel, and the brain switches to anaerobic glycolysis and ATP production. It is thought that the ATP cycle is a fundamental component of the brain and cognitive function. A 2014 study published in The Journal of Neuroscience showed that supplementation of creatine increased phosphocreatine levels as well as muscle ATP production and enhanced cerebral glucose uptake. Creatine was found to boost brain energy production, promote normal mitochondrial biogenesis, and protect against oxidative stress. Additionally, it was found that creatine supplementation not only supported the production of muscle energy over a 4 hour period, it also improved learning and memory retention. It was also found that creatine supplementation protected the brain from aging-induced cognitive deterioration. In the next section you will read about the benefits of creatine-loading. For more on creatine and its role in the brain health we encourage you to review the scientific research on this topic. Similar articles: